Clinical evidence
The clinical evidence behind our therapies
Every therapy at Axiva is grounded in peer-reviewed research. Below, we summarize the evidence behind each program in plain language — with links to the published studies so you can read the science yourself.
On this page
How we evaluate the science
Our standards for adopting new therapies
Axiva adopts a therapy only when the evidence supports it. Before any treatment enters our protocols, our medical leadership reviews the peer-reviewed literature, evaluates safety and candidacy, and defines how the therapy will be monitored. We favor treatments with published clinical research and established safety profiles over trends, and we are transparent about what the evidence does — and does not yet — show.
Every plan is supervised by a board-certified physician or advanced-practice provider, with dosing and follow-up tailored to the individual. As the science evolves, so do our protocols: we revisit our therapies against new research and adjust accordingly. This disciplined, evidence-first approach is why our patients can trust that the care they receive is grounded in medicine, not marketing.
We are transparent about what the evidence does — and does not yet — show.
Therapy area
Medical Weight Management
Medically supervised weight management at Axiva is built on GLP-1 receptor agonist therapy (such as semaglutide and tirzepatide), paired with nutrition guidance, body-composition tracking, and physician monitoring. In large peer-reviewed clinical trials, GLP-1 therapies have produced significant, sustained weight reduction compared with lifestyle changes alone.
Average body-weight reduction reported in NEJM-published GLP-1 trials.
Selected research — 2 sources
- 01NEJM · 10.1056/NEJMoa2206038“clinical evidence showing up to 26.6% weight loss”View source
- 02Applied Clinical TrialsView source
Therapy area
Testosterone & Male Hormone Therapy
Testosterone optimization is among the most extensively studied areas of hormonal medicine. When testosterone is appropriately managed and monitored, peer-reviewed research associates therapy with improvements in lean muscle mass, energy, mood, cognition, libido, and metabolic markers in men with clinically low testosterone.
Selected research — 13 sources
- 01PubMed Central · PMC6966696“Cohen et al., 2020”View source
- 02PubMed Central · PMC7880314“Bhasin, 2021”View source
- 03PubMed Central · PMC10022718“Kresch et al., 2023”View source
- 04The Lancet · PIIS2666-7568(23)00169-1“Hudson et al., 2023”View source
- 05ScienceDirect“Pasiakos et al., 2019”View source
- 06Oxford Academic“Behre et al., 1997”View source
- 07Wiley · 10.1111/and.12633“Lasaite et al., 2016”View source
- 08PubMed · PMID 11445632“Cherrier et al., 2001”View source
- 09PubMed · PMID 19179815View source
- 10PubMed · PMID 26966591View source
- 11Wiley · 10.1111/andr.12867View source
- 12PubMed · PMID 28781213View source
- 13PubMed · PMID 24712761View source
Therapy area
Female Hormone Therapy
Hormone optimization for women — including bioidentical estrogen, progesterone, and testosterone where indicated — is supported by a substantial research base. Peer-reviewed studies link individualized therapy to relief from perimenopausal and menopausal symptoms and to improvements in quality of life, guided by testing and ongoing medical oversight.
Selected research — 4 sources
- 01PubMed Central · PMC3127562View source
- 02PubMed · PMID 26316239View source
- 03PubMed · PMID 18775609View source
- 04PubMed · PMID 25279570View source
Therapy area
IV Vitamin Therapy
Intravenous and intramuscular nutrient delivery bypasses the digestive system, achieving substantially higher bioavailability than oral supplements for select vitamins and minerals. Research supports IV and IM routes where rapid or more complete absorption matters, delivered in a medically supervised setting.
Bioavailability of nutrients delivered intravenously, versus a fraction of that taken orally.
Selected research — 3 sources
- 01PubMed Central · PMC10745386“can break down much of what you take in”View source
- 02SciTechnol · Article 27010“nearly 100% bioavailability compared to the 20–50% absorption of oral supplements”View source
- 03PubMed Central · PMC5748737View source
Therapy area
Longevity, NAD+ & Peptides
Our longevity protocols center on NAD+ and its precursor nicotinamide riboside (NR / Niagen®), alongside targeted peptides. A growing body of peer-reviewed research examines NAD+ biology in cellular energy production, DNA repair, and healthy aging. Axiva applies these therapies conservatively and under medical supervision.
Selected research — 11 sources
- 01medRxiv · 10.1101/2024.06.06.24308565View source
- 02PubMed · PMID 37216171“May help strengthen and restore skin resilience”View source
- 03PubMed · PMID 27508874“Preserving muscle strength”View source
- 04PubMed · PMID 22819213“Mitochondrial vitality”View source
- 05PubMed · PMID 24813611“Contributes to DNA repair”View source
- 06PubMed · PMID 24483238“Mitigates the impact of oxidative stress”View source
- 07PubMed Central · PMC6751327“Supports balanced neurotransmitter activity”View source
- 08NIDA“May ease withdrawal effects and curb cravings during addiction recovery”View source
- 09PubMed · PMID 17161604“May enhance natural energy production within cells, helping to reduce fatigue…”View source
- 10PubMed · PMID 29232252“Potentially guards against age-related cognitive decline and neurodegenerative changes…”View source
- 11PubMed Central · PMC6787556“May enhance mental clarity and cognitive function, while easing anxiety or low mood…”View source
Therapy area
Sexual Wellness
Sexual health is closely tied to hormonal and vascular function. Our protocols draw on established approaches to hormone optimization and sexual medicine, individualized to each patient and delivered under clinical oversight.
Selected research — 1 source
- 01Oxford Academic · J. Sexual MedicineView source
Therapy area
Aesthetic Medicine
Our aesthetic treatments use FDA-cleared neuromodulators, dermal fillers, and collagen-stimulating biostimulators (such as Sculptra®), performed by licensed clinicians trained in facial anatomy. Outcomes emphasize subtle, natural-looking results and patient safety.
Selected research — 2 sources
- 01FDA“FDA-approved facial injectables”View source
- 02PubMed Central · PMC8081460“According to a 2021 clinical study”View source
Evidence, by the numbers
Grounded in published research, not marketing
A disciplined, evidence-first approach: every therapy we offer is reviewed against the peer-reviewed literature before it enters our protocols.
Citations link to the published source so you can read the science yourself. Individual results vary; nothing here is a guarantee of outcome, and any therapy is offered only after a clinician confirms it is safe and appropriate for you.
Plain-language terms
Glossary
A quick reference for the terms used throughout this page.
- GLP-1 receptor agonists
- A class of medications (such as semaglutide and tirzepatide) that mimic a natural gut hormone to regulate appetite and blood sugar, used in medical weight management.
- NAD+
- Nicotinamide adenine dinucleotide — a coenzyme central to cellular energy production and DNA repair that naturally declines with age.
- Nicotinamide riboside (NR / Niagen®)
- A precursor the body converts into NAD+, used to support NAD+ levels.
- Peptides
- Short chains of amino acids that signal specific functions in the body, used in targeted regenerative and recovery protocols.
- Bioidentical hormones (BHRT)
- Hormones structurally identical to those the body produces, used to restore hormonal balance.
- Lipotropic injection
- A blend of B-vitamins and amino acids that supports fat metabolism, sometimes given alongside a weight program.
- Bioavailability
- The proportion of a nutrient or drug that actually reaches circulation — higher with IV/IM delivery than with most oral supplements.
- IV / IM
- Intravenous (into a vein) and intramuscular (into a muscle) delivery routes that bypass digestion for higher absorption.
- Biostimulator
- An injectable (such as Sculptra®) that stimulates the body to produce its own collagen over time.
- Neuromodulator
- An injectable (such as botulinum toxin) that temporarily relaxes targeted muscles to soften lines.
Have questions about the evidence?
We’ll walk you through the research behind any therapy.
Our providers are happy to explain what the science means for your care — and what it does, and doesn’t, promise.